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首页> 外文OA文献 >Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
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Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans

机译：中药提取物纯净化合物对六种口腔念珠菌的有效抗真菌活性以及氟康唑对耐偶氮念珠菌的白色念珠菌的协同作用

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摘要

This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
机译：本研究旨在评估四种中药（TCM）提取物的体外抗真菌活性。使用标准的纸片扩散法和肉汤微量稀释法评估了伪laric acid B，龙胆苦素，大黄酸和alion的抑制作用。他们针对六种口服念珠菌，白念珠菌，光滑念珠菌，热带念珠菌，克鲁斯念珠菌，dubliniensis和guilliermondii念珠菌进行了测试，包括来自HIV阴性，HIV阳性和Sjögren综合征患者的临床分离株。研究发现，伪laric acid B具有最强的抗真菌作用，并且与所有六个假丝酵母菌以及分离自HIV阴性，HIV阳性和干燥综合征的患者分离的真菌均具有相似的抗真菌活性。 MIC值范围为16至128μg/ mL。更有趣的是，观察到假laric acid B与氟康唑的协同作用。我们建议假laric acid B可能是治疗口腔念珠菌病的潜在治疗性杀菌剂。

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